Which lesion is described as exophytic and pedunculated, interfering with eating?

The lesion characterized as exophytic and pedunculated, which can interfere with eating, is commonly identified as a papilloma. Papillomas are benign epithelial tumors that often present as fleshy, wart-like growths. They typically appear as projections from the mucosal surface and can vary in size, often having a stalk (or peduncle), which allows them to be described as pedunculated.

This pedunculated nature contributes to the potential interference with eating, as their location and movement during mastication can cause discomfort or obstruction. Additionally, papillomas are commonly found in the oral cavity, making them particularly relevant in discussions regarding lesions that can impact eating and swallowing.

In contrast, while fibromas may also appear as growths, they are usually not as prominently exophytic or pedunculated and tend to be more sessile. Mucoceles are fluid-filled lesions and do not exhibit the same pedunculated growth pattern. Keratoacanthoma, although it can also show exophytic growth, typically presents with a different clinical appearance and behavior than a papilloma. Thus, the characteristics of exophytic, pedunculated lesions point directly to papilloma as the correct answer.