What is a common differential diagnosis for a lesion at the commissure of the lips?

A lesion at the commissure of the lips can present with several differential diagnoses, but squamous cell carcinoma is significant due to its potential severity and the characteristics of lesions that can occur in this area. Squamous cell carcinoma can manifest as an ulcerated, non-healing lesion or a scaled plaque, and its location at the lip commissures makes it particularly notable as this area can be susceptible to sun damage and other irritants.

While angular cheilitis, contact dermatitis, and herpes simplex virus infections are all relevant considerations for lesions near the lips, squamous cell carcinoma stands out as a diagnosis that necessitates a careful examination, especially in patients with risk factors such as fair skin, a history of prolonged sun exposure, or immunocompromised status.

Recognizing the features of a lesion that might suggest malignancy is vital in medical practice, and therefore squamous cell carcinoma is a serious consideration that must be made when assessing any lesion at the commissure of the lips.