What is a common cause of a pleomorphic adenoma in the mandibular angle?

Pleomorphic adenomas, often referred to as benign mixed tumors, commonly occur in the salivary glands and can occasionally present in the mandibular angle. Trauma is a recognized factor associated with the development of these tumors as it can stimulate changes in the salivary gland tissue. When the gland is subjected to injury or stress, it may undergo cellular changes leading to neoplastic growth.

This form of benign tumor is characterized by its diverse histological structure, which is why it is termed "pleomorphic." Typically, these adenomas arise from the ductal and myoepithelial cells of the salivary glands.

While the other factors listed—such as infection, genetic factors, and radiation exposure—can play roles in the development of various neoplasms or benign conditions within the oral cavity and surrounding structures, trauma specifically has a more direct correlation with mechanical injury leading to the transformation and proliferation of the glandular tissue in this specific context.